Research Publications

The Department is actively involved in research by having the distinction of running externally funded R & D projects worth Rs. 10 crores from various Govt. of India agencies. There are list of publications from deprtment of Biotechnology & Bioinformatics are shown in the table.

Sl_No.

Publication Details

01

Kumar Pedapati, R., Pragyandipta, P., Pranathi Abburi, N., Chirra, N., Kantevari, S., & Naik, P. K. (2023). Antiproliferative Noscapinoids Bearing an Amidothiadiazole Scaffold as Apoptosis Inducers: Design, Synthesis and Molecular Docking. Chemistry & Biodiversity, 20(2), e202201089.

02

Pragyandipta P, Naik MR, Bastia B, Naik PK. Development of 9-(N-arylmethylamino) congeners of noscapine: the microtubule targeting drugs for the management of breast cancer. 3 Biotech. 2023 Feb;13(2):38. doi: 10.1007/s13205-022-03445-3. Epub 2023 Jan 9. PMID: 36636578; PMCID: PMC9829942.

03

Pedapati RK, Chirra N, Abburi NP, Bollikonda R, Alekhya D, Sridhar B, Naik PK*, Kantevari S* (2022). Substrate-directed synthesis of isocoumarin and 3-ylidenephthalide conjugated noscapinoids and their antiproliferative activities. Chemistry An Asian Journal, doi.org/10.1002/asia.202201131. ISSN: 1861-471X

04

Cheruvanachari P, Pattnaik S, Mishra M, Pragyandipta P, Naik PK (2022). Terpinen-4-ol, an active constituent of Kewda essential oil, mitigates biofilm forming ability of multidrug resistant Staphyococcus aureus and Klebsiella pneumoniae, 12, J. Biologically Act. Prod. Nat., 12(5): 406-420, doi: 10.1080/22311866 2022 2154264.

05

Patra A, Satpathy S, Naik PK, Kazi M, Hussain MD (2022). Folate receptor-targeted PLGA-PEG nanoparticles for enhancing the activity of genistein in ovarian cancer. Artificial Cells, Nanomedicine and Biotechnology, 50(1): 228-239.DOI: 10.1080/21691401.2022.2118758

06

Naik M, Behera S, Indur S, Babu SK, Naik PK (2022). Elemental, nutritional, phytochemical profiling and antioxidant activity of Cordia obliqua Willd (Clammy Cherry): an important underutilized forest tree of Eastern India. Journal of Applied Biology and Biotechnology Vol. 11(1), 195-199. DOI: 10.7324/JABB 2023.110127

07

Champati BB, Padhiari BM, Ray A, Jena S, Sahoo A, Pattnaik J, Mohanty S, Naik PK, Panda PC, Nayak S (2022). Assessment of variation in shatavarin IV content in Asparagus racemosus through HPTLC analysis and identification of elite germplasm from Eastern India. Pharmacognosy Magazine. DOI: 10.4103/pm.pm_51_22

08

Soppina P, Patel N, Shewale DJ, Rai A, Sivaramkrishnan S, Naik PK, Sopinna V (2022). Kinesin-3 motors are fine-tuned at the molecular level to endow distinct mechanical outputs. BMC Biology, 20:177, 1-23. https://doi.org/10.1186/s12915-022-01370-8

09

Kumar Pedapati, R., Pragyandipta, P., Pranathi Abburi, N., Chirra, N., Kantevari, S., & Naik, P. K. (2023). Antiproliferative Noscapinoids Bearing an Amidothiadiazole Scaffold as Apoptosis Inducers: Design, Synthesis and Molecular Docking. Chemistry & Biodiversity, 20(2), e202201089.

10

Behera S, Monalisa K, Meher RK, Mohapatra S, Madkami SK, Das PK, Naik PK, Naik SK (2022). Phytochemical fidelity and therapeutic activity of micropropagated Curcuma amada Roxb.: A valuable medicinal herb, Industrial Crops and Products, 176, https://doi.org/10.1016/j.indcrop.2021.114401 [ISSN 0926-6690].

11

Padhiari BM, Ray A, Champati BB, Jena S, Sahoo A, Kuanar A, Halder T, Ghosh B, Naik PK, Patnaik J, Mohanty S, Panda PC, Nayak S (2022). Artificial neural network (ANN) modl for prediction and optimization of bacoside A content in Bacopa monnieri: a statistical approach and experimental validation. Plant Biosystem, https://doi.org/10.1080/11263504.2022.2048278

12

Radha G, Naik PK, Lopus M (2022). In vitro characterization and molecular dynamic simulation of shikonin as a tubulin-targeed anticancer agent. Computers in Biology and Medicine, 147. doi.org/10.1016/j.compbiomed.2022.105789. [ISSN: 0010-4825]

13

Behera S, Chauhan VBS, Pati K, Bansode V, Nedunchezhiyan M, Verma AK, Monalisa K, Naik PK, Naik SK (2022). Biology and biotechnological aspect of sweet potato (Ipomoea batatas L.): a commercially important tuber crop. Planta, 256:40. Doi.org/10.1007/s00425-022-03938-8. [ISSN: 0032-0935]

14

Pragyandipta P, Meher RK, Nagireddy PKR, Pedapati RK, Kantevari S, Naik PK* (2022). Structure based design of tubulin binding 9-arylimino noscapinoids: chemical synthesis and experimental validation against breast cancer cell lines. Analytical Chemistry Letters, 12(1): 29-43. DOI: 10.1080/22297928.2021.2009029. [ISSN: 2229-7928]

15

Kumar R, Salar RK, Naik PK, Yadav M, Kumar A, Kumar A, Yogi R, Kumar M, Chhokar V (2022). Elucidation of genetic diversity and population structure of sixty genotypes of Aloe vera using AFLP markers. South African Journal of Botany, 147: 1146-1155. https://doi.org/10.1016/j.sajb.2021.06.008 [ISSN: 0254-6299]

16

Dash SG, Kantevari S, Guru SK, Naik PK* (2021). Combination of docetaxel and newly synthesized 9-Br-trimethoxybenzyl noscapine improve tubulin binding and enhances antitumor activity in breast cancer cells. Computers in Biology and Medicine, 139, 104996, doi: 10.1016/j.compbiomed.2021.104996. [ISSN: 0010-4825]

17

Sahoo PK, Aparna S, Naik PK, Singh SB, Das SK (2021). Bisphenol A exposure induces neurobehavioral deficits and neurodegeneration through induction of oxidative stress and activated caspase-3 expression in zebrafish brain. Journal of Biochemical and Molecular Toxicology, 35(10): e22873, doi: 10.1002/jbt.22873. [ISSN: 1099-0461]

18

Meher RK, Pragyandipta P, Pedapati RK, Nagireddy PKR, Kantevari S, Nayek AK, Naik PK* (2021). Rational design of novel N-alkyl amine analogues of noscapine, their chemical synthesis and cellular activity as potent anticancer agents. Chemical Biology and Drug Design, DOI: 10.1111/cbdd.13901. [ISSN: 1747-0285]

19

Dash SG, Kantevari S, Pandey SK, Naik PK* (2021) Synergistic interaction of N-3-Br-benzyl-noscapine and docetaxel abrogates oncogenic potential of breast cancer cells. Chemical Biology and Drug Design DOI: 10.1111/cbdd.13902. [ISSN: 1747-0285]

20

Patel AK, Meher RK, Nagireddy PK, Pedapati RK, Pragyandipta P, Kantevari S, Naik MR, Naik PK* (2021) Rational design, chemical synthesis and cellular evaluation of novel 1,3-diynyl derivatives of noscapine as potent tubulin binding anticancer agents. Journal of Molecular Graphics and Modelling, 106, 107933 doi: 10.1016/j.jmgm.2021.107933 [ISSN: 1093-3263]

21

Dash SG, Kantevari S, Naik PK* (2021) Combination regimen of amino-noscapine and docetaxel for evaluation of anticancer activity. 10.1080/22297928.2021.1896380 UGC Approved, Analytical Chemistry Letter, 11(2), 215-229. [ISSN: 2229-7928]

22

Pragyandipta P, Meher RK, Naik MR, Nagireddy PKR, Pedapati RK, Kantevari S, Naik PK* (2021) In silico inspired design of 1,3-diynyl congeners of noscapine as promising tubulin binding anticancer agent: chemical synthesis and cellular activity with breast cancer cell lines. Chemistry Select, 6, 3500-3511. doi.org/10.1002/slct.202004723. [ISSN: 2365-6549]

23

Patel AK, Meher RK, Nagireddy PK, Pragyandipta P, Pedapati RK, Kantevari S, Naik PK* (2021) 9-Arylimino noscapinoids as potent tubulin binding anticancer agent: chemical synthesis and cellular evaluation against breast tumour cells. SAR and QSAR in Environmental Research, doi: 10.1080/ 1062936X.2021.1891567. [ISSN: 1029-046X]

24

Meher RK, Nagireddy PKR, Pragyandipta P, Kantevari S, Singh SK, Kumar V, Naik PK*(2021) In silico design of novel tubulin binding 9-arylimino derivatives of noscapine, their chemical synthesis and cellular activity as potent anticancer agents against breast cancer. Journal of Biomolecular Structure and Dynamics, Feb. 25, 1-12. doi: 10.1080/07391102.2021.1889668. [ISSN: 0739-1102]

25

Anothra P, Pradhan D, Naik PK, Ghosh G, Rath G (2021). Development and characterization of 5-fluorouracil nanofibrous film for the treatment of stomach cancer. Journal of Drug Delivery Science and Technology, 61, February, 102219. doi.org/10.1016/j.jddst.2020.102219, [ISSN: 1773-2247]

26

Induar S, Behera BC, Dubey D, Naik PK (2021). Proximate and sensory properties of Dioscorea bulbifera composite flour made cookies and cake. Asian Journal of Biological and Life Sciences, DOI: 10.5530/ajbls.2020.9. [ISSN: 2278-5957]

27

Rajendran SS, Naik PK, Shankar S, Subramanian U, Asaithambi N (2021). A mixed analysis on coping and social support needs of breast cancer survivors in Chennai, India. Psychology and Education 58(2):9158-9169. DOI: 10.17762/pae.v58i2.3620 [ISSN: 0033-3077]

28

Rajendran SS, Naik PK, Shankar S, Asaithambi N, Arunachalam SS, Periasamy G, Natesan M (2021). Female breast cancer survivor’s perspectives on hope and spirituality needs-a mixed study approach. Psychology and Education 58(2): 9771-9780.DOI: 10.17762/pae.v58i2.3835 [ISSN: 0033-3077]

29

Rajendran SS, Naik PK, Asaithambi N, Shankar S (2021). Impact of selected perceived needs on quality of life of breast cancer survivors. Annals of Romanian Society for Cell Biology 25(4): 850-859. [ISSN: 2067-3019]

30

Rajendran SS, Naik PK, Subramaniam R, Asaithambi N, Shankar S (2021). Perceived need experience of breast cancer survivors seeking health care – a qualitative approach. Psychology and Education 58(3): 3361-3367. DOI: 10.17762/pae.v58i3.4495 [ISSN: 0033-3077]

31

Rajendran SS, Naik PK, Arunachalam SS (2021). Scientometrics of the emerging trends in nursing research related to perceived needs of breast cancer survivors. Biosc. Biotech. Res. Comm. 14(1): 435-440. [ISSN: 0974-6455]

32

Rajendran SS, Naik PK, Venkatesan A, Asaithambi N, Murugesan K, Shankar S, Arunachalam SS (2021). A descriptive analysis of the psychosocial status of breast cancer survivors from Chennai, India. Biosc. Biotech. Res. Comm. 14(1): 382-386. [ISSN: 0974-6455]

33

Sahu DK, Pradhan D, Naik PK, Kar B, Ghosh G, Rath G (2020). Smart polymeric eye gear: A possible preventive measure against ocular transmission of COVID-19. Medical Hypothesis 144, 110288. doi: 10.1016/j.mehy.2020.110288 [ISSN: 0306-9877]

34

Pradhan D, Biswasroy P, Naik PK, Ghos G, Rath G (2020). A review of current interventions for COVID-19 prevention. Archives of Medical Research, 51(5): 363-374. DOI: 10.1016/j.arcmed.2020.04.020. [ISSN: 0188-4409]

35

Kumar A, Naik PK, Pradhan D, Ghos G, Rath G (2020). Mucoadhesive formulations: innovations, merits, drawbacks and future outlook. Pharmaceutical Development and Technology, 25(7): 797-814. DOI: 10.1080/10837450.2020.1753771 [ISSN: 1083-7450]

36

Naik PK, Dubey D, Cheruvanachari P, Pattnaik A, Babu SK (2020), In vitro evaluation of antibacterial and antioxidant properties of an Indian medicinal plant: Celastrus paniculatus. Journal of Biomedical and Pharmaceutical Research, 9(1): 98-104. DOI:10.32553/jbpr.v9i1.726 [ISSN: 2278-5957]

37

Dash SG, Suri C, Nagireddy PKR, Kantevari S, Naik PK* (2020) Rational design of 9-vinyl-phenyl noscapine as potent tubulin binding anticancer agent and evaluation of the effects of its combination on docetaxel. Journal of Biomolecular Structure and Dynamics, Jul 1, 1-14. doi: 10.1080/07391102.2020.1785945. [ISSN: 0739-1102]

38

Rajendran SS, Naik PK, Arunachalam SS (2020). A psychosocial wellbeing of breast cancer survivors – an overview of evidence base nursing research. European Journal of Molecular & Clinical Medicine 7(3): 4834-4841. [ISSN: 2515-8260]

39

Rajendran SS, Naik PK, Kasinathan K, Murudan A, Ibrahim R, Asaithambi N (2020). Sleep quality, fatigue and medication adherence among breast cancer survivors at Chennai - a descriptive study. European Journal of Molecular & Clinical Medicine 7(3): 1426-1439. [ISSN: 2515-8260]

40

Rajendran SS, Naik PK, Asaithambi N, Arunachalam SS, Shankar S, Venkatesan A (2020). Sociodemographic status of breast cancer survivors in Chennai. Biosc. Biotech. Res. Comm. 13(10): 315-321. [ISSN: 0974-6455]

41

Rajendran SS, Naik PK, Arunachalam SS, Asaithambi N, Shankar S (2020). Psychosocial wellbeing status of breast cancer survivours – an observational study. Biosc. Biotech. Res. Comm. 13(10): 322-327.[ISSN: 0974-6455]

42

Pradhan M, Suri C, Choudhary S, Naik PK, Lopus M (2018) Elucidation of the anticancer potential and tubulin isotype-specific interactions of β-sitosterol. Journal of Biomolecular Structure and Dynamics, 36(1):195-208. DOI: 10.1080/07391102.2016.1271749 [ISSN: 0739-1102]

43

Meher RK, Naik MR, Bastia B, Naik PK* (2018) Comparative evaluation of anti-angiogenic effects of noscapine derivatives. Bioinformation, 14(5): 236-240. DOI: 10.6026/97320630014236 [ISSN: 0973-2063]

44

Kumari P, Dixit V, Tiwari AK, Saxena S, Vishvakarma NK, Naik PK, Shukla D (2018) Computer assisted designing of triazole derivative of noscapine as tubulin binding anticancer drug. Asian Journal of Pharmaceutical and Clinical Research, 11(2): 69-75. DOI: 10.22159/ajpcr.2018.v11s2.28586 [ISSN: 2455-3891]

45

Bhoyar MS, Mishra GP, Naik PK, Singh SB (2018) Evaluation of antioxidant capacities and total polyphenols in various edible parts of Capparis spinosa L. collected from trans-Himalayas. Defense Life Sciences Journal, 3(2): 140-145. DOI: 10.14429/dlsj.3.12570 [ISSN: 2456-379X]

46

Bastia B, Kumar K, Kumar SN, Naik PK, Behera NR, Jain AK (2018). Image segmentation and association analysis of endothelin-1 and CD-31 expression in tobacco smokers’ placenta using automated nearest neighbour and genetic algorithm. Journal of Biological Sciences and Medicine, 4(1): 1-9. [ISSN: 2455-5266]

47

Mahaddalkar T, Naik PK, Choudhary S, Manchukonda N, Kantevari S, Lopus M (2017) Structural investigations into the binding mode of a novel noscapine analogue, 9-(4-vinylphenyl) noscapine, with tubulin by biochemical analyses and molecular dynamic simulations. Journal of Biomolecular Structure and Dynamics, 35(11): 2475-2484. DOI: 10.1080/07391102.2016.1222969 [ISSN: 0739-1102]

48

Kumar R, Naik PK, Kumar A, Aggarwal H, Kumar A and Chhokar V (2016) A combined approach using RAPD, ISSR and bioactive compound for the assessment of genetic diversity in Aloe vera (L.) Burn.f. Indian Journal of Biotechnology, 14: 538-549. [ISSN: 0972-5849]

49

Akbar A, Kuanar A, Joshi AK, Sandeep IS, Mohanty S, Naik PK, Mishra A, Nayak S (2016). Development of prediction model and experimental validation in predicting the curcumin content of turmeric (Curcuma longa L.). Frontiers in Plant Sciences, Vol 7, Article 1507, DOI: 10.3389/fpls.2016.01507. DOI: 10.3389/fpls.2016.01507 [ISSN: 1664-462X]

50

Sandeep IS, Kuanar A, Akbar A, Kar B, Das S, Mishra A, Sial P, Naik PK, Nayak S, Mohanty S (2016) Agroclimatic zone based metabolic profiling of turmeric (Curcuma longa L.) for phytochemical yield optimization. Industrial Crops and Products, 85: 229-240. DOI: 10.1016/j.indcrop.2016.03.007 [ISSN: 0926-6690]

51

Kumar M, Naik PK, Patlan S, Chhokar V (2016) Assessment of genetic variation among Asparagus racemosus genotypes using molecular marker and biochemical markers. Journal of Medicinal Plants Studies, 4(6): 117-123. [ISSN 2320-3862]

52

Kumar M, Naik PK, Sarla, Chhokar V (2016). Genetic variations in Asparagus racemosus, an endangered medicinal herb endemic to India using RAPD markers. British Biotechnology Journal, 10(2): 1-11. [ISSN: 2231-2927]

53

Rani S, Kumar M, Naik PK, Phulia SK and Chhokar V (2016). ESRα exon polymorphism coupled with protein modeling in relation to reproductive traits in murrah buffaloes. International Journal of Pharma and Bio Sciences, 7(4): 856-868. DOI:10.22376/ijpbs.2016.7.4.b856-868